An international team of researchers under the leadership of the University of Bonn has now found a cause for this link. Their knowledge comes thanks to an animal that is known among aquarium owners for its characteristic pigmentation: the zebrafish. The results have now been published in the Journal of Clinical Investigation.
Zebrafish without stripes Dowling-Degos disease is a hereditary pigmentation disorder that generally progresses harmlessly.
Dowling-Degos disease is a hereditary pigmentation disorder that generally progresses harmlessly. However, some of those affected also develop severe skin inflammation.
Zebrafish larvae
© Benjamin Odermatt, Uni Bonn
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Zebrafish Core Facility
Damian Ralser et al.: Mutations in gamma-secretase subunit–encoding PSENEN underlie Dowling-Degos disease associated with acne inversa; Journal of Clinical Investigation; DOI: 10.1172/JCI90667
Prof. Regina Betz
Institute of Human Genetics
University of Bonn
E-mail: regina.betz@uni-bonn.de
Prof. Benjamin Odermatt
Anatomical Institute
Zebrafish Core Facility
University of Bonn
E-mail: b.odermatt@uni-bonn.de