A short-term oat-based diet appears to be surprisingly effective at reducing the cholesterol level. This is indicated by a trial by the University of Bonn, which has now been published in the journal Nature Communications. The participants suffered from a metabolic syndrome – a combination of high body weight, high blood pressure, and elevated blood glucose and blood lipid levels. They consumed a calorie-reduced diet, consisting almost exclusively of oatmeal, for two days. Their cholesterol levels then improved significantly compared to a control group. Even after six weeks, this effect remained stable. The diet apparently influenced the composition of microorganisms in the gut. The metabolic products, produced by the microbiome, appear to contribute significantly to the positive effects of oats

The powerhouse of the cells – known as mitochondria – appear to be able to influence the number of lipid droplets in the cell. A mechanism that is actually intended for a completely different purpose plays a central role in this. This is shown by a recent study by the University of Bonn and University Hospital Bonn and the University of Freiburg. The results have now been published in the journal Nature Cell Biology.

A new AI-based method reconstructs spatial information about where immune cells were originally located in an organ, even after these cells have been removed from the tissue and analyzed individually. To accomplish this, Researchers at the University Hospital Bonn (UKB) and the University of Bonn use the transcriptome, i.e., the entirety of all messenger RNA transcripts produced by genes within a cell at a given time. The work has now been published in the journal Advanced Science and introduces the new MERLIN algorithm.

Die NGS Core Facility Bonn wurde im Rahmen der offiziellen LEAF-Zertifizierungsfeier am 22. Januar 2026 mit dem LEAF-Bronze-Zertifikat ausgezeichnet. 

The zebrafish serves as a model organism for researchers around the world: it can be used to study important physiological processes that also take place in a similar form in the human body. It is therefore routinely used in the search for possible active substances against diseases. Researchers at the University of Bonn have now described an innovative way to do this. In this process, the larvae fish are made a bit more "human-like". This humanization could make the search for active pharmaceutical substances much more efficient. The results of the pilot study have been published in the journal Cell Chemical Biology.

During sperm production, an enormous amount of DNA has to be packed into a very small space without breaking anything. A central role is played by certain proteins around which the DNA thread is wrapped - the protamines. A recent study by the University of Bonn provides new insights into this important mechanism. The results have been published in the journal PLoS Genetics.

How do pigeons find their way home safely over distances of many kilometers? A research team from the University Hospital Bonn (UKB), the University of Bonn, the University of Duisburg-Essen, and the Max Planck Institute for Behavioral Biology has now discovered a previously unknown mechanism: specific immune cells in the liver may help the birds detect the Earth’s magnetic field. The findings have now been published in the journal Science

For the immune system to effectively combat pathogens, antibody responses must be precisely controlled. So-called follicular regulatory T cells (Tfr cells) play a key role in this process by limiting excessive immune responses and helping to maintain immune tolerance. Researchers at the University Hospital Bonn (UKB) and the University of Bonn have now developed a robust laboratory method that allows Tfr cells to be generated from precursor cells and studied in a targeted manner. The results were recently published in the journal Cellular & Molecular Immunology.